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Synthetic peptide Phase II Human data available

Peptide database · P-028

Cibinetide

ARA-290; helix B surface peptide

Cibinetide is an 11-amino-acid peptide designed to mimic erythropoietin-associated tissue-protective signalling without classical erythropoiesis.

01

Molecular profile

Molecular profile

Molecule class
Synthetic peptide
Origin
Synthetic fragment
Primary target system
Innate-repair-receptor-Komplex aus EPOR und CD131
Development stage
Clinical development
Structure note

Nicht hämatopoetisches Peptidanalogon aus der Helix-B-Oberfläche von Erythropoietin.

02

Mechanism and signalling

Mechanism and signalling

A heteromeric EPOR–CD131 receptor complex is proposed, potentially affecting resolution of inflammation and tissue protection.

03

Scientific classification

Scientific classification

This profile maps Cibinetide to the research areas neuro, immune. Molecule class, evidence level, development stage and regulatory status are separated so that preclinical findings are not confused with authorised uses.

Neuroactive research

Neuropeptides and analogues in models of neuronal signalling, stress and pain.

Immune, barrier and antimicrobial research

Innate immunity, epithelial barriers and antimicrobial peptide functions.

04

Evidence base

Phase II

PreclinicalEarly human dataClinical dataPhase IIPhase IIIApproval and post-marketing data

Phase II studies have investigated neuropathic and inflammatory settings. General medicinal approval has not been granted.

05

Regulatory status

Investigational substance

Investigational substance

The substance remains in clinical development and is not authorised as a generally available medicine. Trial status and regulatory assessment may change.

06

Safety and use notice

No dosing or administration recommendation

The available evidence does not establish safe self-directed use. This profile intentionally provides no dosing, sourcing or administration guidance.

07

Sources and registries

Sources and registries