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Synthetic peptide Preclinical No robust human data

Peptide database · P-005

KPV

Lys-Pro-Val; α-MSH(11-13)

KPV is the C-terminal tripeptide fragment of alpha-MSH and is studied in models of epithelial barrier function, inflammation and antimicrobial activity.

01

Molecular profile

Molecular profile

Molecule class
Synthetic peptide
Origin
Endogenous fragment
Primary target system
Entzündungs- und Barriereprozesse; melanocortinunabhängige Mechanismen werden diskutiert
Development stage
Preclinical development
Structure note

C-terminales Tripeptidfragment von alpha-MSH.

02

Mechanism and signalling

Mechanism and signalling

Reported effects involve pro-inflammatory signalling and microbial interactions. Some observed activity may not be fully explained by classical melanocortin receptors.

03

Scientific classification

Scientific classification

This profile maps KPV to the research areas immune, gastrointestinal, dermatology. Molecule class, evidence level, development stage and regulatory status are separated so that preclinical findings are not confused with authorised uses.

Immune, barrier and antimicrobial research

Innate immunity, epithelial barriers and antimicrobial peptide functions.

Gastrointestinal signalling

Peptide-based regulation of secretion, motility and the intestinal barrier.

Dermatology and melanocortin research

Skin matrix, pigmentation biology, copper peptides and melanocortin signalling.

04

Evidence base

Preclinical

PreclinicalEarly human dataClinical dataPhase IIPhase IIIApproval and post-marketing data

The evidence is predominantly preclinical. Controlled human trials, standardised formulations and robust long-term safety data are lacking.

05

Regulatory status

Not generally authorised

Not generally authorised

This research substance has no general medicinal authorisation in Germany or the EU. Labels such as “research peptide” do not replace regulatory approval.

06

Safety and use notice

No dosing or administration recommendation

The available evidence does not establish safe self-directed use. This profile intentionally provides no dosing, sourcing or administration guidance.

07

Sources and registries

Sources and registries