Molecular profile
Molecular profile
- Molecule class
- Cyclic peptide
- Origin
- Synthetic analogue
- Primary target system
- Guanylatcyclase-C
- Development stage
- Authorised active substance
Disulfidreiches 14-Aminosäuren-Peptid und Guanylatcyclase-C-Agonist.
Mechanism and signalling
Mechanism and signalling
Local guanylate-cyclase-C activation increases intracellular and luminal cGMP, affecting secretion and nociceptive signalling.
Scientific classification
Scientific classification
This profile maps Linaclotid to the research areas gastrointestinal. Molecule class, evidence level, development stage and regulatory status are separated so that preclinical findings are not confused with authorised uses.
Peptide-based regulation of secretion, motility and the intestinal barrier.
Evidence base
Approval and post-marketing data
Randomised trials and regulatory assessments are available. They do not support systemic or unlicensed uses.
Regulatory status
Authorised in the EU/multiple markets
The active substance is used in authorised medicines in multiple jurisdictions. Authorisations apply only to defined products, indications, quality standards and conditions of use.
Safety and use notice
No dosing or administration recommendation
The available evidence does not establish safe self-directed use. This profile intentionally provides no dosing, sourcing or administration guidance.
Sources and registries