Molecular profile
Molecular profile
- Molecule class
- Cyclic peptide
- Origin
- Synthetic analogue
- Primary target system
- Guanylatcyclase-C
- Development stage
- Authorised active substance
Disulfidreiches Uroguanylin-Analogon.
Mechanism and signalling
Mechanism and signalling
The peptide activates luminal guanylate cyclase C and modulates cGMP-dependent intestinal secretion and sensitivity.
Scientific classification
Scientific classification
This profile maps Plecanatid to the research areas gastrointestinal. Molecule class, evidence level, development stage and regulatory status are separated so that preclinical findings are not confused with authorised uses.
Peptide-based regulation of secretion, motility and the intestinal barrier.
Evidence base
Approval and post-marketing data
Evidence includes approval trials for specific oral medicines. It cannot be transferred to other formulations or research products.
Regulatory status
Specifically approved in the U.S.
The substance has a specific U.S. approval. This does not constitute general authorisation in Germany or the European Union, nor approval of unlicensed products.
Safety and use notice
No dosing or administration recommendation
The available evidence does not establish safe self-directed use. This profile intentionally provides no dosing, sourcing or administration guidance.
Sources and registries