Molecular profile
Molecular profile
- Molecule class
- Cyclic peptide
- Origin
- Synthetic analogue
- Primary target system
- Melanocortin-4-Rezeptor
- Development stage
- Authorised active substance
Zyklisches Peptidanalogon und selektiver MC4R-Agonist.
Mechanism and signalling
Mechanism and signalling
Activation of hypothalamic MC4R targets a central node in hunger and energy homeostasis.
Scientific classification
Scientific classification
This profile maps Setmelanotid to the research areas metabolism, rare_disease. Molecule class, evidence level, development stage and regulatory status are separated so that preclinical findings are not confused with authorised uses.
Pathways related to glucose homeostasis, appetite, energy expenditure and body composition.
Peptide therapeutics for molecularly defined rare diseases and specialised treatment concepts.
Evidence base
Approval and post-marketing data
Approval trials concern molecularly defined rare diseases. Findings do not generalise to common obesity.
Regulatory status
Authorised in the EU/multiple markets
The active substance is used in authorised medicines in multiple jurisdictions. Authorisations apply only to defined products, indications, quality standards and conditions of use.
Safety and use notice
No dosing or administration recommendation
The available evidence does not establish safe self-directed use. This profile intentionally provides no dosing, sourcing or administration guidance.
Sources and registries